Host Genomics of the HIV-1 Reservoir Size and Its Decay Rate During Suppressive Antiretroviral Treatment.

doi:10.1097/QAI.0000000000002473

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Host Genomics of the HIV-1 Reservoir Size and Its Decay Rate During Suppressive Antiretroviral Treatment.

Journal of acquired immune deficiency syndromes (1999) - 1 Dec 2020

Thorball Christian W, Borghesi Alessandro, Bachmann Nadine, Von Siebenthal Chantal, Vongrad Valentina, Turk Teja, Neumann Kathrin, Beerenwinkel Niko, Bogojeska Jasmina, Roth Volker, Kok Yik Lim, Parbhoo Sonali, Wieser Mario, Böni Jürg, Perreau Matthieu, Klimkait Thomas, Yerly Sabine, Battegay Manuel, Rauch Andri, Schmid Patrick, Bernasconi Enos, Cavassini Matthias, Kouyos Roger D, Günthard Huldrych F, Metzner Karin J, Fellay Jacques

Abstract excerpt

BACKGROUND: The primary hurdle for the eradication of HIV-1 is the establishment of a latent viral reservoir early after primary infection. Here, we investigated the potential influence of human genetic variation on the HIV-1 reservoir size and its decay rate during suppressive antiretroviral treatment. SETTING: Genome-wide association study and exome sequencing study to look for host genetic determinants of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-HIV Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Genome, Human

Share to Genome-Wide Association Study

Share to Genomics

Share to HIV-1

Share to HIV Infections

Share to Time Factors

Source

Open in PubMed

Identifiers

PMID: 33136754
DOI: 10.1097/QAI.0000000000002473

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Host Genomics of the HIV-1 Reservoir Size and Its Decay Rate During Suppressive Antiretroviral Treatment.PMID 33136754Read ↗

Host genomics of the HIV-1 reservoir size and its decay rate during suppressive antiretroviral treatmentSemantic proximity Read ↗

Host variation in type I interferon signaling genes (MX1), C-C chemokine receptor type 5 gene, and major histocompatibility complex class I alleles in treated HIV+ noncontrollers predict viral reservoir size.Semantic proximity Read ↗

HIV Proviral Burden, Genetic Diversity, and Dynamics in Viremic Controllers Who Subsequently Initiated Suppressive Antiretroviral Therapy.Semantic proximity Read ↗

The replication-competent HIV reservoir is a genetically restricted, younger subset of the overall pool of HIV proviruses persisting during therapy, which is highly genetically stable over timeSemantic proximity Read ↗

The latent HIV reservoir: current advances in genetic sequencing approachesSemantic proximity Read ↗

Differences in expression of tumor suppressor, innate immune, inflammasome, and potassium/gap junction channel host genes significantly predict viral reservoir size during treated HIV infectionSemantic proximity Read ↗

Rapid biphasic decay of intact and defective HIV DNA reservoir during acute treated HIV diseaseSemantic proximity Read ↗

HIV-1 virome profiling using HIV-PULSE to guide therapeutic and curative interventions.Semantic proximity Read ↗

Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansionSemantic proximity Read ↗

HIV reservoirs are dominated by genetically younger and clonally enriched provirusesSemantic proximity Read ↗

The HIV-1 reservoir landscape in persistent elite controllers and transient elite controllersSemantic proximity Read ↗

Rapid Biphasic Decay of Intact and Defective HIV DNA Reservoir During Acute Treated HIV DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.