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Article

Antibody accessibility determines location of spike surface mutations in SARS-CoV-2 variants.

PLoS computational biology - 1 Jan 2023

von Bülow Sören, Sikora Mateusz, Blanc Florian E C, Covino Roberto, Hummer Gerhard

Abstract excerpt

The steady emergence of SARS-CoV-2 variants gives us a real-time view of the interplay between viral evolution and the host immune defense. The spike protein of SARS-CoV-2 is the primary target of antibodies. Here, we show that steric accessibility to antibodies provides a strong predictor of mutation activity in the spike protein of SARS-CoV-2 variants, including Omicron. We introduce an antibody accessibility...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36693110
DOI: 10.1371/journal.pcbi.1010822
PMCID: PMC9897577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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