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Article

Interactions between FUS and the C-terminal Domain of Nup62 are Sufficient for their Co-phase Separation into Amorphous Assemblies.

Journal of molecular biology - 15 Mar 2023

Kumar Meenakshi Sundaram, Stallworth Karly M, Murthy Anastasia C, Lim Su Min, Li Nan, Jain Aastha, Munro James B, Fawzi Nicolas L, Lagier-Tourenne Clotilde, Bosco Daryl A

Abstract excerpt

Deficient nucleocytoplasmic transport is emerging as a pathogenic feature of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), including in ALS caused by mutations in Fused in Sarcoma (FUS). Recently, both wild-type and ALS-linked mutant FUS were shown to directly interact with the phenylalanine-glycine (FG)-rich nucleoporin 62 (Nup62) protein, where FUS WT/ Nup62 interactions were enriched...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36690069
DOI: 10.1016/j.jmb.2023.167972
PMCID: PMC10329203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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