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Western diet augments metabolic and arterial dysfunction in a sex-specific manner in outbred, genetically diverse mice

6 Jan 2023

Abstract excerpt

Western diet (WD), characterized by excess saturated fat and sugar intake, is a major contributor to obesity and metabolic and arterial dysfunction in humans. However, these phenotypes are not consistently observed in traditional inbred, genetically identical mice. Therefore, we sought to determine the effects of WD on visceral adiposity and metabolic/arterial function in UM-HET3 mice, an outbred, genetically...

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PMID: 36687716
DOI: 10.3389/fnut.2022.1090023

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