Immunodominant antibody responses directed to SARS-CoV-2 hotspot mutation sites and risk of immune escape.

doi:10.3389/fimmu.2022.1010105

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Article

Immunodominant antibody responses directed to SARS-CoV-2 hotspot mutation sites and risk of immune escape.

Frontiers in immunology - 1 Jan 2022

Oliveira Jamille Ramos, Ruiz Cesar Manuel Remuzgo, Machado Rafael Rahal Guaragna, Magawa Jhosiene Yukari, Daher Isabela Pazotti, Urbanski Alysson Henrique, Schmitz Gabriela Justamante Händel, Arcuri Helen Andrade, Ferreira Marcelo Alves, Sasahara Greyce Luri, de Medeiros Giuliana Xavier, Júnior Roberto Carlos Vieira Silva, Durigon Edison Luiz, Boscardin Silvia Beatriz, Rosa Daniela Santoro, Schechtman Deborah, Nakaya Helder I, Cunha-Neto Edecio, Gadermaier Gabriele, Kalil Jorge, Coelho Verônica, Santos Keity Souza

Abstract excerpt

Introduction: Considering the likely need for the development of novel effective vaccines adapted to emerging relevant CoV-2 variants, the increasing knowledge of epitope recognition profile among convalescents and afterwards vaccinated with identification of immunodominant regions may provide important information. Methods: We used an RBD peptide microarray to identify IgG and IgA binding regions in serum of 71...

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Identifiers

PMID: 36685521
DOI: 10.3389/fimmu.2022.1010105
PMCID: PMC9849925

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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