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Mutations involving TGFB and MAPK may be associated with malignancy in granular cell tumors.

Genes, chromosomes & cancer - 1 May 2023

Dehner Carina A, Moon Tyler, Lyu Yang, Zhang Xiaochun, Zhou Zhaohe, Yang Kuangying, Chrisinger John S A, Griffin Anthony, Wunder Jay, Dickson Brendan C, Hirbe Angela C

Abstract excerpt

Granular cell tumors (GrCTs) are mesenchymal neoplasms of presumed schwannian differentiation that may present as solitary or multifocal lesions with excision usually being curative. A minority of cases, however, show histological features associated with an increased risk for metastasis and are highly aggressive leading to death in about a third of cases. While benign and malignant cases have been shown to...

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PMID: 36680529
DOI: 10.1002/gcc.23123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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