Article
In-frame insertions of SOX10 are highly enriched and characterize a distinct transcriptomic profile in gastrointestinal schwannomas.
The Journal of pathology - 1 Jul 2025
Lee Pei-Hang, Huang Shih-Chiang, Lee Jen-Chieh, Li Sung-Chou, Tsai Jen-Wei, Chang Yi-Ming, Kao Yu-Chien, Fan Wen-Lang, Chang Ching-Di, Chen Hui-Chun, Li Chih-Hao, Hu Chia-Fa, Liu Ting-Ting, Wu Pao-Shu, Nam Mann-Hua, Yu Shih-Chen, Wang Jui-Chu, Huang Hsuan-Ying
Abstract excerpt
Gastrointestinal schwannomas are molecularly and histologically distinct from their non-gastrointestinal counterparts, lacking NF2 alterations, although the primary drivers of these tumors are barely understood. A recent study has identified SOX10 in-frame insertions in schwannomas, particularly in intracranial non-vestibular lesions, whereas their role in gastrointestinal schwannomas remains unexplored. Whole...
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