Molecular Characterization of Juxtaglomerular Cell Tumors: Evidence of Alterations in MAPK-RAS Pathway.

doi:10.1016/j.modpat.2024.100492

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Article

Molecular Characterization of Juxtaglomerular Cell Tumors: Evidence of Alterations in MAPK-RAS Pathway.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2024

Lobo João, Canete-Portillo Sofia, Pena Maria Del Carmen Rodriguez, McKenney Jesse K, Aron Manju, Massicano Felipe, Wilk Brandon M, Gajapathy Manavalan, Brown Donna M, Baydar Dilek E, Matoso Andres, Rioux-Leclerq Nathalie, Pan Chin-Chen, Tretiakova Maria S, Trpkov Kiril, Williamson Sean R, Rais-Bahrami Soroush, Mackinnon Alexander C, Harada Shuko, Worthey Elizabeth A, Magi-Galluzzi Cristina

Abstract excerpt

Juxtaglomerular cell tumor (JGCT) is a rare neoplasm, part of the family of mesenchymal tumors of the kidney. Although the pathophysiological and clinical correlates of JGCT are well known, as these tumors are an important cause of early-onset arterial hypertension refractory to medical treatment, their molecular background is unknown, with only few small studies investigating their karyotype. Herein we describe...

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PMID: 38614322
DOI: 10.1016/j.modpat.2024.100492

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