Article
Androgen Action via the Androgen Receptor in Neurons Within the Brain Positively Regulates Muscle Mass in Male Mice.
Endocrinology - 1 Oct 2017
Davey Rachel A, Clarke Michele V, Russell Patricia K, Rana Kesha, Seto Jane, Roeszler Kelly N, How Jackie M Y, Chia Ling Yeong, North Kathryn, Zajac Jeffrey D
Abstract excerpt
Although it is well established that exogenous androgens have anabolic effects on skeletal muscle mass in humans and mice, data from muscle-specific androgen receptor (AR) knockout (ARKO) mice indicate that myocytic expression of the AR is dispensable for hind-limb muscle mass accrual in males. To identify possible indirect actions of androgens via the AR in neurons to regulate muscle, we generated neuron-ARKO...
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