Article
ACTN3 genotype influences androgen response in developing murine skeletal muscle.
Science advances - 29 Aug 2025
Roeszler Kelly N, See Michael, Meehan Lyra R, Lima Giscard, Kolliari-Turner Alexander, Alexander Sarah E, Landen Shanie, Wood Harrison D, Tiong Chrystal F, Chen Weiyi, Mustafa Tomris, Houweling Peter J, Eynon Nir, Lamon Severine, Pitsiladis Yannis, Handelsman David J, Rossello Fernando J, Ramialison Mirana, North Kathryn N, Seto Jane T
Abstract excerpt
Androgens act through androgen receptor (AR) to maintain muscle mass. Evidence suggests that this pathway is influenced by "the gene for speed," ACTN3 (α-actinin-3). Given that one in five people lack α-actinin-3, it is possible that they may respond to androgens differently. Here, we show that α-actinin-3 deficiency decreases AR in muscles of mice and humans (in males and females) and that AR positively...
Read the complete abstract on PubMedTopics
- Actinin
- Animals
- Muscle, Skeletal
- Mice
- Androgens