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HPV is a cargo for the COPI sorting complex during virus entry

20 Jan 2023

Abstract excerpt

During entry, human papillomavirus (HPV) traffics from the cell surface to the endosome and then to the trans-Golgi network (TGN) and Golgi apparatus. HPV must transit across the TGN/Golgi and exit these compartments to reach the nucleus to cause infection, although how these steps are accomplished is unclear. Combining cellular fractionation, unbiased proteomics, and gene knockdown strategies, we identified the...

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PMID: 36662862
DOI: 10.1126/sciadv.adc9830

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