Article
Translocation of the papillomavirus L2/vDNA complex across the limiting membrane requires the onset of mitosis.
PLoS pathogens - 1 May 2017
Calton Christine M, Bronnimann Matthew P, Manson Ariana R, Li Shuaizhi, Chapman Janice A, Suarez-Berumen Marcela, Williamson Tatum R, Molugu Sudheer K, Bernal Ricardo A, Campos Samuel K
Abstract excerpt
The human papillomavirus type 16 (HPV16) L2 protein acts as a chaperone to ensure that the viral genome (vDNA) traffics from endosomes to the trans-Golgi network (TGN) and eventually the nucleus, where HPV replication occurs. En route to the nucleus, the L2/vDNA complex must translocate across limiting intracellular membranes. The details of this critical process remain poorly characterized. We have developed a...
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