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Article

Vesicular trafficking permits evasion of cGAS/STING surveillance during initial human papillomavirus infection.

PLoS pathogens - 1 Nov 2020

Uhlorn Brittany L, Jackson Robert, Li Shuaizhi, Bratton Shauna M, Van Doorslaer Koenraad, Campos Samuel K

Abstract excerpt

Oncogenic human papillomaviruses (HPVs) replicate in differentiating epithelium, causing 5% of cancers worldwide. Like most other DNA viruses, HPV infection initiates after trafficking viral genome (vDNA) to host cell nuclei. Cells possess innate surveillance pathways to detect microbial components or physiological stresses often associated with microbial infections. One of these pathways, cGAS/STING, induces...

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Identifiers

PMID: 33253291
DOI: 10.1371/journal.ppat.1009028
PMCID: PMC7728285

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