Article
Inflammatory Cell Infiltration Into Islets Without PD-L1 Expression Is Associated With the Development of Immune Checkpoint Inhibitor-Related Type 1 Diabetes in Genetically Susceptible Patients.
Diabetes - 1 Apr 2023
Kawata Satoshi, Kozawa Junji, Yoneda Sho, Fujita Yukari, Kashiwagi-Takayama Risa, Kimura Takekazu, Hosokawa Yoshiya, Baden Megu Y, Uno Sae, Uenaka Rikako, Namai Kazuyuki, Koh Yoko, Tomimaru Yoshito, Hirata Haruhiko, Uemura Motohide, Nojima Satoshi, Morii Eiichi, Eguchi Hidetoshi, Imagawa Akihisa, Shimomura Iichiro
Abstract excerpt
Immune checkpoint inhibitors (ICIs) could cause type 1 diabetes (T1D). However, the underlying mechanism remains unclear. We immunohistochemically analyzed pancreatic specimens from three individuals with ICI-related T1D, and their histopathological data were compared those from three patients who had received ICI therapy but did not develop T1D (non-T1D) and seven normal glucose-tolerant subjects as control...
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