HER2-driven breast cancer suppression by the JNK signaling pathway

Abstract excerpt

The HER2 + subtype of human breast cancer is associated with the malignant transformation of luminal ductal cells of the mammary epithelium. The sequence analysis of tumor DNA identifies loss of function mutations and deletions of the MAP2 K4 and MAP2 K7 genes that encode direct activators of the JUN NH 2 -terminal kinase (JNK). We report that in vitro studies of human mammary epithelial cells with CRISPR-induced...

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