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Article

NFE2L2 Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells.

Cancer research - 15 Mar 2023

Guan Li, Nambiar Dhanya K, Cao Hongbin, Viswanathan Vignesh, Kwok Shirley, Hui Angela B, Hou Yuan, Hildebrand Rachel, von Eyben Rie, Holmes Brittany J, Zhao Junfei, Kong Christina S, Wamsley Nathan, Zhang Weiruo, Major Michael B, Seol Seung W, Sunwoo John B, Hayes D Neil, Diehn Maximilian, Le Quynh-Thu

Abstract excerpt

Radiotherapy (RT) is one of the primary treatments of head and neck squamous cell carcinoma (HNSCC), which has a high-risk of locoregional failure (LRF). Presently, there is no reliable predictive biomarker of radioresistance in HNSCC. Here, we found that mutations in NFE2L2, which encodes Nrf2, are associated with a significantly higher rate of LRF in patients with oral cavity cancer treated with surgery and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36652552
DOI: 10.1158/0008-5472.CAN-22-1903
PMCID: PMC10023320

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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