STK11/LKB1 Mutations in NSCLC Are Associated with KEAP1/NRF2-Dependent Radiotherapy Resistance Targetable by Glutaminase Inhibition.

doi:10.1158/1078-0432.CCR-20-2859

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Article

STK11/LKB1 Mutations in NSCLC Are Associated with KEAP1/NRF2-Dependent Radiotherapy Resistance Targetable by Glutaminase Inhibition.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2021

Sitthideatphaiboon Piyada, Galan-Cobo Ana, Negrao Marcelo V, Qu Xiao, Poteete Alissa, Zhang Fahao, Liu Diane D, Lewis Whitney E, Kemp Haley N, Lewis Jeff, Rinsurongkawong Waree, Giri Uma, Lee J Jack, Zhang Jianjun, Roth Jack A, Swisher Stephen, Heymach John V

Abstract excerpt

PURPOSE: Radiotherapy with or without chemotherapy is a mainstay of treatment for locally advanced non-small cell lung cancer (NSCLC), but no predictive markers are currently available to select patients who will benefit from these therapies. In this study, we investigated the association between alterations in STK11/LKB1, the second most common tumor suppressor in NSCLC, and response to radiotherapy as well as...

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PMID: 33323404
DOI: 10.1158/1078-0432.CCR-20-2859
PMCID: PMC8138942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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