Article
Protein phosphatase 2A activators reverse age-related behavioral changes by targeting neural cell senescence.
Aging cell - 1 Mar 2023
Xing Jun, Chen Kehua, Gao Shuaiyun, Pousse Mélanie, Ying Yilin, Wang Bo, Chen Lianxiang, Wang Cuicui, Wang Lei, Hu Weiguo, Lu Yiming, Gilson Eric, Ye Jing
Abstract excerpt
The contribution of cellular senescence to the behavioral changes observed in the elderly remains elusive. Here, we observed that aging is associated with a decline in protein phosphatase 2A (PP2A) activity in the brains of zebrafish and mice. Moreover, drugs activating PP2A reversed age-related behavioral changes. We developed a transgenic zebrafish model to decrease PP2A activity in the brain through knockout...
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