Article
Association of rs3135500 and rs3135499 Polymorphisms in the MicroRNA-binding Site of Nucleotide-binding Oligomerization Domain 2 (NOD2) Gene with Susceptibility to Rheumatoid Arthritis.
Iranian journal of allergy, asthma, and immunology - 17 Apr 2021
Ehtesham Naeim, Alani Behrang, Mortazavi Deniz, Azhdari Sara, Kenarangi Taiebe, Esmaeilzadeh Emran, Pakzad Bahram
Abstract excerpt
The nucleotide-binding oligomerization domain 2 (NOD2) is the key regulator of inflammatory responses and has been involved in the pathogenesis of rheumatoid arthritis (RA). Laboratory and in silico evaluations have demonstrated that some polymorphisms in 3'UTR of NOD2 gene could influence the secondary structure of this region and similarly thermodynamic features of hybridization site and finally deregulate the...
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