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Crosstalk via ICAM-1 enhances supportive phenotype of stellate cells and drives hepatocyte proliferation in iPSC-derived hepatic organoids.

Stem cell reports - 14 Oct 2025

Mochida Tomohiro, Miyoshi Masato, Kakinuma Sei, Shimizu Taro, Tsuchiya Jun, Watakabe Keiya, Inada Kento, Kaneko Shun, Kawai-Kitahata Fukiko, Murakawa Miyako, Nitta Sayuri, Nakagawa Mina, Watanabe Mamoru, Asahina Yasuhiro, Okamoto Ryuichi

Abstract excerpt

The interaction between hepatic stellate cells (HSCs) and hepatocytes contributes to HSC activation and liver regeneration; however, the mechanisms in humans remain unclear, particularly the significance of their direct contact and the role of cell adhesion molecules. In this study, we established a novel contact co-culture organoids using induced pluripotent stem cell (iPSC)-derived hepatic stellate-like cells...

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Identifiers

PMID: 40972589
DOI: 10.1016/j.stemcr.2025.102642
PMCID: PMC12790731

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