Article
Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus.
BMC medical genomics - 5 Aug 2010
Bell Christopher G, Teschendorff Andrew E, Rakyan Vardhman K, Maxwell Alexander P, Beck Stephan, Savage David A
Abstract excerpt
BACKGROUND: Diabetic nephropathy is a serious complication of diabetes mellitus and is associated with considerable morbidity and high mortality. There is increasing evidence to suggest that dysregulation of the epigenome is involved in diabetic nephropathy. We assessed whether epigenetic modification of DNA methylation is associated with diabetic nephropathy in a case-control study of 192 Irish patients with...
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