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Article

Estrogen receptor alpha signaling in dendritic cells modulates autoimmune disease phenotype in mice.

EMBO reports - 6 Mar 2023

Khaw Yee Ming, Anwar Shehata, Zhou Jinyan, Kawano Tasuku, Lin Po-Ching, Otero Ashley, Barakat Radwa, Drnevich Jenny, Takahashi Tomoko, Ko CheMyong Jay, Inoue Makoto

Abstract excerpt

Estrogen is a disease-modifying factor in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) via estrogen receptor alpha (ERα). However, the mechanisms by which ERα signaling contributes to changes in disease pathogenesis have not been completely elucidated. Here, we demonstrate that ERα deletion in dendritic cells (DCs) of mice induces severe neurodegeneration in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36633157
DOI: 10.15252/embr.202154228
PMCID: PMC9986829

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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