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Article

Estrogen regulates T helper 17 phenotype and localization in experimental autoimmune arthritis

13 Feb 2015

Abstract excerpt

INTRODUCTION: The incidence and progression of many autoimmune diseases are sex-biased, which might be explained by the immunomodulating properties of endocrine hormones. Treatment with estradiol potently inhibits experimental autoimmune arthritis. Interleukin-17-producing T helper cells (Th17) are key players in several autoimmune diseases, particularly in rheumatoid arthritis. The aim of this study was to...

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PMID: 25888974
DOI: 10.1186/s13075-015-0548-y

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