Estrogen receptor α contributes to T cell–mediated autoimmune inflammation by promoting T cell activation and proliferation

Abstract excerpt

Women are more frequently affected by autoimmune disorders than men. A role for estrogen was suggested by the observation that the development of inflammatory bowel disease was associated with oral contraceptive use. Women also respond to infection and vaccination with higher antibody production and a T helper 2 (TH2) cell–dominant immune responses, whereas men usually show TH1 cell–biased immune responses.

Topics

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• Cytokine Signaling Pathways and Interactions
• Immune Cell Function and Interaction
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

61e707ca-6a1f-5b34-a439-44e470639750

DOI

10.1530/ey.15.14.1