Site- and allele-specific polycomb dysregulation in T-cell leukaemia.

doi:10.1038/ncomms7094

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Article

Site- and allele-specific polycomb dysregulation in T-cell leukaemia.

Nature communications - 23 Jan 2015

Navarro Jean-Marc, Touzart Aurore, Pradel Lydie C, Loosveld Marie, Koubi Myriam, Fenouil Romain, Le Noir Sandrine, Maqbool Muhammad Ahmad, Morgado Ester, Gregoire Claude, Jaeger Sebastien, Mamessier Emilie, Pignon Charles, Hacein-Bey-Abina Salima, Malissen Bernard, Gut Marta, Gut Ivo G, Dombret Hervé, Macintyre Elizabeth A, Howe Steven J, Gaspar H Bobby, Thrasher Adrian J, Ifrah Norbert, Payet-Bornet Dominique, Duprez Estelle, Andrau Jean-Christophe, Asnafi Vahid, Nadel Bertrand

Abstract excerpt

T-cell acute lymphoblastic leukaemias (T-ALL) are aggressive malignant proliferations characterized by high relapse rates and great genetic heterogeneity. TAL1 is amongst the most frequently deregulated oncogenes. Yet, over half of the TAL1(+) cases lack TAL1 lesions, suggesting unrecognized (epi)genetic deregulation mechanisms. Here we show that TAL1 is normally silenced in the T-cell lineage, and that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25615415
DOI: 10.1038/ncomms7094
PMCID: PMC4317503

Genes

TAL1
RAG1

Provenance

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