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Article

Role of epigenetics in the etiology of hypospadias through penile foreskin DNA methylation alterations

11 Jan 2023

Abstract excerpt

Abnormal penile foreskin development in hypospadias is the most frequent genital malformation in male children, which has increased dramatically in recent decades. A number of environmental factors have been shown to be associated with hypospadias development. The current study investigated the role of epigenetics in the etiology of hypospadias and compared mild (distal), moderate (mid shaft), and severe...

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PMID: 36631595
DOI: 10.1038/s41598-023-27763-5

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