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Article

Is hypospadias a genetic, endocrine or environmental disease, or still an unexplained malformation?

11 Jul 2008

Abstract excerpt

Hypospadias is one of the most frequent genital malformations in the male newborn and results from an abnormal penile and urethral development. This process requires a correct genetic programme, time- and space-adapted cellular differentiation, complex tissue interactions, and hormonal mediation through enzymatic activities and hormonal transduction signals. Any disturbance in these regulations may induce a...

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PMID: 18637150
DOI: 10.1111/j.1365-2605.2008.00899.x

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