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Article

Genome-wide DNA Methylation Profiling of CpG Islands in Hypospadias

17 Aug 2012

Abstract excerpt

PURPOSE: Hypospadias is one of the most frequent genital malformations in the male newborn, and results from abnormal penile and urethral development. The etiology of hypospadias remains largely unknown despite intensive investigations. Fetal androgens have a crucial role in genital differentiation. Recent studies have suggested that molecular mechanisms that underlie the effects of androgens on the fetus may...

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PMID: 22906644
DOI: 10.1016/j.juro.2012.03.047

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