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Article

Dysregulated expression of androgen metabolism genes and genetic analysis in hypospadias.

Molecular genetics & genomic medicine - 1 Aug 2020

Chen Zhongzhong, Lin Xiaoling, Wang Yaping, Xie Hua, Chen Fang

Abstract excerpt

BACKGROUND: The aberrant expression of genes involved in androgen metabolism and genetic contribution are unclear in hypospadias. METHODS: We compared gene expression profiles by RNA sequencing from five non-hypospadiac foreskins, five mild hypospadiac foreskins, and five severe hypospadiac foreskins. In addition, to identify rare coding variants with large effects on hypospadias risk, we carried out whole exome...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32515122
DOI: 10.1002/mgg3.1346
PMCID: PMC7434757

Genes

AR
CYP19A1
CYP11A1
CYP3A4
ESR1
HSD17B14
HSD17B7
HSD3B1
HSD3B7
SLC25A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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