Article

IDH1 and IDH2 Mutations in Tumorigenesis: Mechanistic Insights and Clinical Perspectives

2020-11-01

Abstract excerpt

Genes encoding for isocitrate dehydrogenases 1 and 2, IDH1 and IDH2, are frequently mutated in multiple types of human cancer. Mutations targeting IDH1 and IDH2 result in simultaneous loss of their normal catalytic activity, the production of α-ketoglutarate (α-KG), and gain of a new function, the production of 2-hydroxyglutarate (2–HG). 2-HG is structurally similar to α-KG, and acts as an α-KG antagonist to compe...

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Literature Corpus work: 49a625cb-02b1-5d1f-87a9-4153dc386b34
DOI: 10.17615/bhtg-gb11

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