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Article

Molecular Targeting of the Isocitrate Dehydrogenase Pathway and the Implications for Cancer Therapy.

International journal of molecular sciences - 4 Jul 2024

Ivanov Stanislav, Nano Olger, Hana Caroline, Bonano-Rios Amalia, Hussein Atif

Abstract excerpt

The advent of comprehensive genomic profiling using next-generation sequencing (NGS) has unveiled an abundance of potentially actionable genetic aberrations that have shaped our understanding of the cancer biology landscape. Isocitrate dehydrogenase (IDH) is an enzyme present in the cytosol (IDH1) and mitochondria (IDH2 and IDH3). In the mitochondrion, it catalyzes the irreversible oxidative decarboxylation of...

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Identifiers

PMID: 39000443
DOI: 10.3390/ijms25137337
PMCID: PMC11242572

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