Article
IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors.
Proceedings of the National Academy of Sciences of the United States of America - 3 Jul 2017
Whitehouse Gavin, Gray Elizabeth, Mastoridis Sotiris, Merritt Elliot, Kodela Elisavet, Yang Jennie H M, Danger Richard, Mairal Marta, Christakoudi Sofia, Lozano Juan J, Macdougall Iain C, Tree Timothy I M, Sanchez-Fueyo Alberto, Martinez-Llordella Marc
Abstract excerpt
CD4+CD25+FOXP3+ Tregs constitute a heterogeneous lymphocyte subpopulation essential for curtailing effector T cells and establishing peripheral tolerance. Calcineurin inhibitors (CNIs) are among the most effective agents in controlling effector T-cell responses in humans. However, CNIs also reduce the size of the Treg pool. The functional consequences of this negative effect and the mechanisms responsible remain...
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