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Article

Structural systems biology approach delineate the functional implications of SNPs in exon junction complex interaction network.

Journal of biomolecular structure & dynamics - 1 Jan 2023

V M Datta Darshan, Sivaramakrishnan Venketesh, Arvind Kumar K

Abstract excerpt

In eukaryotes, transcripts that carry premature termination codons (PTC) leading to truncated proteins are degraded by the Nonsense Mediated Decay (NMD) machinery. Missense and nonsense Single Nucleotide Polymorphisms (SNPs) in proteins belonging to Exon junction complex (EJC) and up-frameshift protein (UPF) will compromise NMD leading to the accumulation of truncated proteins in various diseases. The EJC and UPF...

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Identifiers

PMID: 36617892
DOI: 10.1080/07391102.2022.2164355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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