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Article

Annotating Mutational Effects on Proteins and Protein Interactions: Designing Novel and Revisiting Existing Protocols.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017

Li Minghui, Goncearenco Alexander, Panchenko Anna R

Abstract excerpt

In this review we describe a protocol to annotate the effects of missense mutations on proteins, their functions, stability, and binding. For this purpose we present a collection of the most comprehensive databases which store different types of sequencing data on missense mutations, we discuss their relationships, possible intersections, and unique features. Next, we suggest an annotation workflow using the...

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Identifiers

PMID: 28188534
DOI: 10.1007/978-1-4939-6747-6_17
PMCID: PMC5388446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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