Article
Association Between Immunosenescence Phenotypes and Pre-frailty in Older Subjects: Does Cytomegalovirus Play a Role?
The journals of gerontology. Series A, Biological sciences and medical sciences - 14 Mar 2019
Cao Dinh Hung, Bautmans Ivan, Beyer Ingo, Mets Tony, Onyema Oscar Okwudiri, Forti Louis Nuvagah, Renmans Wim, Vander Meeren Sam, Jochmans Kristin, Vermeiren Sofie, Vella-Azzopardi Roberta, Njemini Rose
Abstract excerpt
Frailty is highly prevalent in old age and confers an important mortality risk. Although the causes of frailty are multiple, immunosenescence (IS)-predominantly driven by cytomegalovirus (CMV)-has been implicated in its pathophysiology. Thus far, research examining the association between IS and frailty states is sparse and equivocal. On the other hand, evidence is mounting in support of the view that frailty can...
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