Article
Genetic, DNA methylation, and immune profile discrepancies between early-stage single primary lung cancer and synchronous multiple primary lung cancer.
Clinical epigenetics - 7 Jan 2023
Yu Fenglei, Huang Xiaojie, Zhou Danting, Zhao Zhenyu, Wu Fang, Qian Banglun, Wang Qiang, Chen Juan, Liang Qingchun, Jiang Yi, Ding Qi, He Qiongzhi, Tang Jingqun, Wang Xiang, Liu Wenliang, Chen Chen
Abstract excerpt
BACKGROUND: To explore the possible carcinogenesis and help better diagnose and treat patients with synchronous multiple primary lung cancers (sMPLC), we systematically investigated the genetic and DNA methylation profiles of early-stage sMPLC and single primary lung cancer (SPLC) and explored the immune profiles in the tumor microenvironment. METHODS: Hundred and ninety-one patients with 191 nodules in the SPLC...
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