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Article

The role of PARP in DNA repair and its therapeutic exploitation

1 Oct 2011

Abstract excerpt

Historically, PARP inhibitors (PARPi) were developed to potentiate the cytotoxic effect of certain chemotherapeutic agents and are currently being investigated in combination with chemotherapy in diverse cancer types. These agents are also radiosensitisers and clinical trials of PARPi with concurrent radiation are required. It has long been recognised that defective DNA repair pathways lead to tumour...

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PMID: 21989215
DOI: 10.1038/bjc.2011.382

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