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CRISPR‐interceded CHO cell line development approaches

3 Jan 2023

Abstract excerpt

For industrial production of recombinant protein biopharmaceuticals, Chinese hamster ovary (CHO) cells represent the most widely adopted host cell system, owing to their capacity to produce high-quality biologics with human-like posttranslational modifications. As opposed to random integration, targeted genome editing in genomic safe harbor sites has offered CHO cell line engineering a new perspective, ensuring...

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PMID: 36597180
DOI: 10.1002/bit.28329

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