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Article

Sampling the antibiotic resistome.

Science (New York, N.Y.) - 20 Jan 2006

D'Costa Vanessa M, McGrann Katherine M, Hughes Donald W, Wright Gerard D

Abstract excerpt

Microbial resistance to antibiotics currently spans all known classes of natural and synthetic compounds. It has not only hindered our treatment of infections but also dramatically reshaped drug discovery, yet its origins have not been systematically studied. Soil-dwelling bacteria produce and encounter a myriad of antibiotics, evolving corresponding sensing and evading strategies. They are a reservoir of...

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PMID: 16424339
DOI: 10.1126/science.1120800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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