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Article

Genetically predicted C-reactive protein mediates the association between rheumatoid arthritis and atlantoaxial subluxation

16 Dec 2022

Abstract excerpt

Objective: Investigating the causal relationship between rheumatoid arthritis (RA) and atlantoaxial subluxation (AAS) and identifying and quantifying the role of C-reactive protein (CRP) as a potential mediator. Methods: Using summary-level data from a genome-wide association study (GWAS), a two-sample Mendelian randomization (MR) analysis of genetically predicted rheumatoid arthritis (14,361 cases, and 43,923...

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PMID: 36589832
DOI: 10.3389/fendo.2022.1054206

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