Article
Prospective associations of C-reactive protein (CRP) levels and CRP genetic risk scores with risk of total knee and hip replacement for osteoarthritis in a diverse cohort.
Osteoarthritis and cartilage - 1 Aug 2018
Shadyab A H, Terkeltaub R, Kooperberg C, Reiner A, Eaton C B, Jackson R D, Krok-Schoen J L, Salem R M, LaCroix A Z
Abstract excerpt
OBJECTIVE: To examine associations of high-sensitivity C-reactive protein (CRP) levels and polygenic CRP genetic risk scores (GRS) with risk of end-stage hip or knee osteoarthritis (OA), defined as incident total hip (THR) or knee replacement (TKR) for OA. DESIGN: This study included a cohort of postmenopausal white, African American, and Hispanic women from the Women's Health Initiative. Women were followed from...
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