Article
Single-cell and spatial analyses reveal the association between gene expression of glutamine synthetase with the immunosuppressive phenotype of APOE+CTSZ+TAM in cancers.
Molecular oncology - 1 Apr 2023
Wei Jinfen, Yu Wenqi, Chen Juanzhi, Huang Guanda, Zhang Lingjie, Chen Zixi, Hu Meiling, Gong Xiaocheng, Du Hongli
Abstract excerpt
An immunosuppressive state is regulated by various factors in the tumor microenvironment (TME), including, but not limited to, metabolic plasticity of immunosuppressive cells and cytokines secreted by these cells. We used single-cell RNA-sequencing (scRNA-seq) data and applied single-cell flux estimation analysis to characterize the link between metabolism and cellular function within the hypoxic TME of...
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