Article
OLMALINC/OCT4/BMP2 axis enhances osteogenic-like phenotype of renal interstitial fibroblasts to participate in Randall's plaque formation.
Molecular medicine (Cambridge, Mass.) - 29 Dec 2022
Zhu Zewu, Huang Fang, Jiang Yingcheng, Ruan Shuhao, Liu Minghui, Zhang Youjie, Li Yongchao, Chen Jinbo, Cui Yu, Chen Zhiyong, Chen Hequn, Zeng Feng
Abstract excerpt
BACKGROUND: Randall's plaques (RP) are identified as anchored sites for kidney calcium oxalate stones, but the mechanism remains unclear. Given the importance of osteogenic-like cells in RP formation and OCT4 in reprogramming differentiated cells to osteoblasts, the current study explored the potential role of OCT4 in RP formation. METHODS: OCT4 and biomineralization were evaluated in RP, and immunofluorescence...
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