Article
Non-coding RNAs repressive role in post-transcriptional processing of RUNX2 during the acquisition of the osteogenic phenotype of periodontal ligament mesenchymal stem cells.
Developmental biology - 1 Feb 2021
Assis Rahyza I F, Feltran Geórgia da S, Silva Maria Eduarda Salomão, Palma Iasmin Caroline do Rosário, Rovai Emanuel Silva, Miranda Taís Browne de, Ferreira Marcel Rodrigues, Zambuzzi Willian F, Birbrair Alexander, Andia Denise C, da Silva Rodrigo A
Abstract excerpt
Mesenchymal stem cells are candidates for therapeutic strategies in periodontal repair due to their osteogenic potential. In this study, we identified epigenetic markers during osteogenic differentiation, taking advantage of the individual pattern of mesenchymal cells of the periodontal ligament with high (h-PDLCs) and low (l-PDLCs) osteogenic capacity. We found that the involvement of non-coding RNAs in the...
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