Transcription factor HNF4α2 promotes osteogenesis and prevents bone abnormalities in mice with renal osteodystrophy

Abstract excerpt

Renal osteodystrophy (ROD) is a disorder of bone metabolism that affects virtually all patients with chronic kidney disease (CKD) and is associated with adverse clinical outcomes including fractures, cardiovascular events, and death. In this study, we showed that hepatocyte nuclear factor 4α (HNF4α), a transcription factor mostly expressed in the liver, is also expressed in bone, and that osseous HNF4α expression...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Folate and B Vitamins Research
• Share to Genetic Syndromes and Imprinting
• Share to Parathyroid Disorders and Treatments