Article
Small molecules that targeting p53 Y220C protein: mechanisms, structures, and clinical advances in anti-tumor therapy.
Molecular diversity - 1 Oct 2025
Xu Jinglei, Yuan Jiahao, Wang Wenxin, Zhu Xiaoning, Li Jialong, Ma Yule, Liu Shaojie, Feng Jie, Chen Yadong, Lu Tao, Li Hongmei
Abstract excerpt
The p53 protein is regarded as the "Guardian of the Genome," but its mutation is tumor progression and present in more than half of malignant tumors. The pro-metastatic property of mutant p53 makes a strong argument for targeting mutant p53 with new therapeutic strategies. However, mutant p53 was considered as a challenging target for drug discovery due to the lack of small molecular binding pockets. Among them,...
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