Article
Bidirectional Mendelian Randomisation Analysis Provides Evidence for the Causal Involvement of Dysregulation of CXCL9, CCL11 and CASP8 in the Pathogenesis of Ulcerative Colitis.
Journal of Crohn's & colitis - 3 May 2023
Chen Jie, Zhou Yajing, Sun Yuhao, Yuan Shuai, Kalla Rahul, Sun Jing, Zhao Jianhui, Wang Lijuan, Chen Xuejie, Zhou Xuan, Dai Siqi, Zhang Yu, Ho Gwo-Tzer, Xia Dajing, Cao Qian, Liu Zhanju, Larsson Susanna C, Wang Xiaoyan, Ding Kefeng, Halfvarson Jonas, Li Xue, Theodoratou Evropi, Satsangi Jack
Abstract excerpt
BACKGROUND AND AIMS: Systemic inflammation is well recognised to be associated with ulcerative colitis [UC], but whether these effects are causal or consequential remains unclear. We aimed to define potential causal relationship of cytokine dysregulation with different tiers of evidence. METHODS: We first synthesised serum proteomic profiling data from two multicentred observational studies, in which a panel of...
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