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Examining the Feasibility of Using Free Energy Perturbation (FEP+) in Predicting Protein Stability.

Journal of chemical information and modeling - 26 Jun 2017

Ford Melissa Coates, Babaoglu Kerim

Abstract excerpt

The importance of engineering protein stability is well-known and has the potential to impact many fields ranging from pharmaceuticals to food sciences. Engineering proteins can be both a time-consuming and expensive experimental process. The use of computation is a potential solution to mitigating some of the time and expenses required to engineer a protein. This process has been previously hindered by...

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PMID: 28520421
DOI: 10.1021/acs.jcim.7b00002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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