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Article

UHRF1-mediated ferroptosis promotes pulmonary fibrosis via epigenetic repression of GPX4 and FSP1 genes

24 Dec 2022

Abstract excerpt

Pulmonary fibrosis (PF), as an end-stage clinical phenotype of interstitial lung diseases (ILDs), is frequently initiated after alveolar injury, in which ferroptosis has been identified as a critical event aggravating the pathophysiological progression of this disease. Here in, a comprehensive analysis of two mouse models of pulmonary fibrosis developed in our lab demonstrated that lung damage-induced ferroptosis...

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Share to Epigenetics and DNA Methylation
Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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PMID: 36566325
DOI: 10.1038/s41419-022-05515-z

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