Article
The IDH1-R132H mutation aggravates cisplatin-induced acute kidney injury by promoting ferroptosis through disrupting NDUFA1 and FSP1 interaction.
Cell death and differentiation - 1 Feb 2025
Lai Kunmei, Chen Zhimin, Lin Siyi, Ye Keng, Yuan Ying, Li Guoping, Song Yankun, Ma Huabin, Mak Tak W, Xu Yanfang
Abstract excerpt
The IDH1-R132H mutation is implicated in the development of various tumors. Whether cisplatin, a common chemotherapeutic agent, induces more significant renal toxicity in individuals with the IDH1-R132H mutation remains unclear. In this study, we observed that the IDH1-R132H mutation exacerbates mitochondrial lipid peroxidation and dysfunction in renal tubules, rendering the kidneys more susceptible to...
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